› 4f4s

X-ray diffraction
1.9Å resolution

Structure of the yeast F1Fo ATPase c10 ring with bound oligomycin

Released:
DOI: 10.2210/pdb4f4s/pdb
PDB entry 4f4s coloured by chain, front view.
PDB entry 4f4s coloured by chain, side view.
PDB entry 4f4s coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Oligomycin frames a common drug-binding site in the ATP synthase.
Symersky J, Osowski D, Walters DE, Mueller DM
Proc Natl Acad Sci U S A 109 13961-5 (2012)
PMID: 22869738

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP synthase subunit 9, mitochondrial Chains: A, B, C, D, E, K, L, M, N, O
Molecule details ›
Chains: A, B, C, D, E, K, L, M, N, O
Length: 76 amino acids
Theoretical weight: 7.79 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P61829 (Residues: 1-76; Coverage: 100%)
Gene names: ATP9, OLI1, OLI3, PHO2, Q0130
Sequence domains: ATP synthase subunit C
Structure domains: F1F0 ATP synthase subunit C

Ligands and Environments

1 bound ligand:
Ligand EFO 7 x EFO
1 modified residue:
Ligand FME 10 x FME

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: I4122
Unit cell:
a: 75.674Å b: 75.674Å c: 488.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.228
Expression system: Saccharomyces cerevisiae

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Citations

19 review citations

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.
Bernardi et al. (2015)
18 more

6 mentions without citation

Oligomycin frames a common drug-binding site in the ATP synthase.
Symersky et al. (2012)
5 more