› 4f1y

X-ray diffraction
1.79Å resolution

CNQX bound to the ligand binding domain of GluA3

Released:
DOI: 10.2210/pdb4f1y/pdb
PDB entry 4f1y coloured by chain, front view.
PDB entry 4f1y coloured by chain, side view.
PDB entry 4f1y coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM
Biochemistry 51 4015-27 (2012)
PMID: 22512472

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 3 Chains: A, C
Molecule details ›
Chains: A, C
Length: 258 amino acids
Theoretical weight: 28.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19492 (Residues: 417-530, 658-799; Coverage: 30%)
Gene names: GluA3, Glur3, Gria3
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand CNI 2 x CNI
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 50.183Å b: 96.846Å c: 62.229Å
α: 90° β: 107.15° γ: 90°
R-values:
R R work R free
0.208 0.206 0.251
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Noncompetitive antagonists induce cooperative AMPA receptor channel gating.
Shi et al. (2019)
5 more