PDBe 4f12

X-ray diffraction
3.02Å resolution

Crystal structure of the extracellular domain of human GABA(B) receptor GBR2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid type B receptor subunit 2 Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 49.13 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75899 (Residues: 42-466; Coverage: 47%)
Gene names: GABBR2, GPR51, GPRC3B
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2221
Unit cell:
a: 82.684Å b: 142.515Å c: 79.264Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.254
Expression system: Spodoptera frugiperda