Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27) + succinate + formaldehyde + CO(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Lysine-specific demethylase 6B (preferred)
PDBe Complex ID:
PDB-CPX-177634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 6B
Molecule details ›
Chains: A, B
Length: 486 amino acids
Theoretical weight: 54.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 486 amino acids
Theoretical weight: 54.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q5NCY0 (Residues: 1155-1295, 1296-1641; Coverage: 29%)
Sequence domains:
- JmjC domain, hydroxylase
- Lysine-specific demethylase 6/UTY, C-terminal helical domain
- KDM6, GATA-like
