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Human Insulin

X-ray diffraction
1.657Å resolution
PDB entry 4ex1 coloured by chain, front view.
PDB entry 4ex1 coloured by chain, side view.
PDB entry 4ex1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 11457.95 Å2
Buried surface area: 20639.94 Å2
Dissociation area: 4,522.76 Å2
Dissociation energy (ΔGdiss): 62.95 kcal/mol
Dissociation entropy (TΔSdiss): 12.84 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 4ex1, assembly 1, front view.
Insulin A chain in PDB entry 4ex1, assembly 1, side view.
Insulin A chain in PDB entry 4ex1, assembly 1, top view.
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Insulin B chain
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
Insulin B chain in PDB entry 4ex1, assembly 1, front view.
Insulin B chain in PDB entry 4ex1, assembly 1, side view.
Insulin B chain in PDB entry 4ex1, assembly 1, top view.
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