› 4ews

X-ray diffraction
2.59Å resolution

Crystal structure of cholesteryl ester transfer protein in complex with inhibitors

Released:
DOI: 10.2210/pdb4ews/pdb
PDB entry 4ews coloured by chain, front view.
PDB entry 4ews coloured by chain, side view.
PDB entry 4ews coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
Liu S, Mistry A, Reynolds JM, Lloyd DB, Griffor MC, Perry DA, Ruggeri RB, Clark RW, Qiu X
J Biol Chem 287 37321-9 (2012)
PMID: 22961980

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cholesteryl ester transfer protein Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P11597 (Residues: 18-493; Coverage: 100%)
Gene name: CETP
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
5 bound ligands:
Ligand 2OB 2 x 2OB
Ligand DLP 1 x DLP
Ligand PGE 2 x PGE
Ligand CL 1 x CL
Ligand 0RP 1 x 0RP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 69.6Å b: 69.323Å c: 188.233Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.259
Expression system: Cricetulus griseus

Quick links

Citations

7 review citations

Cholesteryl ester transfer protein and its inhibitors.
Shrestha et al. (2018)
6 more

4 mentions without citation

Structure-based mechanism and inhibition of cholesteryl ester transfer protein.
Xue et al. (2023)
3 more