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Study on structure and function relationships in human Pirin with Mn ion

Source organism: Homo sapiens
Biochemical function: dioxygenase activity
Biological process: monocyte differentiation
Cellular component: nuclear body

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EC 1.13.11.24: Quercetin 2,3-dioxygenase

Reaction catalysed:
Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+)
Systematic name:
Quercetin:oxygen 2,3-oxidoreductase (ring-opening)
Alternative Name(s):
  • Flavonol 2,4-oxygenase
  • Quercetin:oxygen 2,3-oxidoreductase (decyclizing)
  • Quercetinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05726
Domain description: Pirin C-terminal cupin domain
Occurring in:
  1. Pirin
The deposited structure of PDB entry 4ewd contains 1 copy of Pfam domain PF05726 (Pirin C-terminal cupin domain) in Pirin. Showing 1 copy in chain A.

PF02678
Domain description: Pirin
Occurring in:
  1. Pirin
The deposited structure of PDB entry 4ewd contains 1 copy of Pfam domain PF02678 (Pirin) in Pirin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. Pirin
IPR012093
Domain description: Pirin
Occurring in:
  1. Pirin
IPR008778
Domain description: Pirin, C-terminal domain
Occurring in:
  1. Pirin
IPR003829
Domain description: Pirin, N-terminal domain
Occurring in:
  1. Pirin
IPR011051
Domain description: RmlC-like cupin domain superfamily
Occurring in:
  1. Pirin

Structure domain

CATH CATH domain
2.60.120.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Pirin
The deposited structure of PDB entry 4ewd contains 2 copies of CATH domain 2.60.120.10 (Jelly Rolls) in Pirin. Showing 2 copies in chain A.

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