› 4ev6

X-ray diffraction
3.2Å resolution

The complete structure of CorA magnesium transporter from Methanocaldococcus jannaschii

Released:
DOI: 10.2210/pdb4ev6/pdb
PDB entry 4ev6 coloured by chain, front view.
PDB entry 4ev6 coloured by chain, side view.
PDB entry 4ev6 coloured by chain, top view.
Source organism: Methanocaldococcus jannaschii DSM 2661
Primary publication:
Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA.
Guskov A, Nordin N, Reynaud A, Engman H, Lundbäck AK, Jong AJ, Cornvik T, Phua T, Eshaghi S
Proc Natl Acad Sci U S A 109 18459-64 (2012)
PMID: 23091000

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cobalt/magnesium transport protein CorA Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 339 amino acids
Theoretical weight: 39.74 KDa
Source organism: Methanocaldococcus jannaschii DSM 2661
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58439 (Residues: 1-317; Coverage: 100%)
Gene names: MJ1033, corA
Sequence domains: CorA-like Mg2+ transporter protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand UMQ 8 x UMQ
Ligand MG 32 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 103.11Å b: 124.83Å c: 111.88Å
α: 90° β: 90.76° γ: 90°
R-values:
R R work R free
0.209 0.205 0.282
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Bacterial Mg2+ homeostasis, transport, and virulence.
Groisman et al. (2013)
4 more

5 mentions without citation

Membrane-spanning α-helical barrels as tractable protein-design targets.
Niitsu et al. (2017)
4 more