4equ

X-ray diffraction
2Å resolution

Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 61.81Å b: 49.04Å c: 133.76Å
α: 90° β: 101.42° γ: 90°
R-values:
R R work R free
0.224 0.223 0.246
Expression system: Escherichia coli