› 4efd

X-ray diffraction
2.45Å resolution

Crystal Structure of an M17 aminopeptidase from Trypanosoma Brucei, Tb427tmp.02.4440

Released:
DOI: 10.2210/pdb4efd/pdb
PDB 4efd coloured by chain and viewed from the front.
PDB 4efd coloured by chain and viewed from the side.
PDB 4efd coloured by chain and viewed from the top.
Source organism: Trypanosoma brucei brucei TREU927
Entry authors: Wernimont AK, Osman KT, Loppnau P, Arrowsmith CH, Edwards AM, Bountra C, Hui R, Lin YH, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosol aminopeptidase domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 522 amino acids
Theoretical weight: 55.48 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q385B0 (Residues: 1-521; Coverage: 100%)
Gene name: Tb11.02.4440
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand SO4 12 x SO4
Ligand MN 8 x MN
Ligand GOL 8 x GOL
Ligand UNX 6 x UNX
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 161.916Å b: 161.74Å c: 176.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.253
Expression system: Escherichia coli

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