PDBe 4dzo

X-ray diffraction
1.76Å resolution

Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting

Released:
Source organism: Homo sapiens
Primary publication:
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Proc. Natl. Acad. Sci. U.S.A. 109 6549-54 (2012)
PMID: 22493223

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitotic spindle assembly checkpoint protein MAD1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6D9 (Residues: 597-718; Coverage: 17%)
Gene names: MAD1, MAD1L1, TXBP181
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P65
Unit cell:
a: 44.767Å b: 44.767Å c: 211.056Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.16 0.197
Expression system: Escherichia coli BL21(DE3)