X-ray diffraction
2.1Å resolution

Crystal structure of Staphylococcus epidermidis D283A mevalonate diphosphate decarboxylase complexed with inhibitor DPGP


Function and Biology Details

Reaction catalysed:
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
diphosphomevalonate decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 332 amino acids
Theoretical weight: 36.83 KDa
Source organism: Staphylococcus epidermidis
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9FD73 (Residues: 1-327; Coverage: 100%)
Gene names: FHG76_00400, FHQ17_11140, I3V53_03435, mvaD
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-BM-B
Spacegroup: C2221
Unit cell:
a: 82.966Å b: 102.05Å c: 155.143Å
α: 90° β: 90° γ: 90°
R R work R free
0.189 0.186 0.239
Expression system: Escherichia coli BL21(DE3)