4dt6

X-ray diffraction
2.6Å resolution

Co-crystal structure of eIF4E with inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Min X, Johnstone S, Walker N, Wang Z

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 38.224Å b: 61.073Å c: 122.439Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.267
Expression system: Escherichia coli