PDBe 4dsn

X-ray diffraction
2.03Å resolution

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 2-189; Coverage: 99%)
  • Best match: P01116-2 (Residues: 2-188)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: R3
Unit cell:
a: 78.638Å b: 78.638Å c: 77.353Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.165 0.206
Expression system: Escherichia coli