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Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH

X-ray diffraction
2.38Å resolution
PDB entry 4dph coloured by chain, front view.
PDB entry 4dph coloured by chain, side view.
PDB entry 4dph coloured by chain, top view.
Source organism: Plasmodium falciparum VS/1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bifunctional dihydrofolate reductase-thymidylate synthase
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Multimeric state: homo dimer
Accessible surface area: 46752.37 Å2
Buried surface area: 11756.3 Å2
Dissociation area: 4,071.39 Å2
Dissociation energy (ΔGdiss): 47.13 kcal/mol
Dissociation entropy (TΔSdiss): 15.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-113002

Macromolecules

Bifunctional dihydrofolate reductase-thymidylate synthase
Chains: A, B
Length: 608 amino acids
Theoretical weight: 71.91 KDa
Source organism: Plasmodium falciparum VS/1
Expression system: Escherichia coli
UniProt:
  • Canonical: D9N170 (Residues: 1-608; Coverage: 100%)
Gene names: DHFR-TS, V1/S
Pfam:
InterPro:
CATH:
Bifunctional dihydrofolate reductase-thymidylate synthase in PDB entry 4dph, assembly 1, front view.
Bifunctional dihydrofolate reductase-thymidylate synthase in PDB entry 4dph, assembly 1, side view.
Bifunctional dihydrofolate reductase-thymidylate synthase in PDB entry 4dph, assembly 1, top view.
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