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IL20/IL201/IL20R2 Ternary Complex

Source organism: Homo sapiens
Biochemical function: interleukin-22 receptor binding
Biological process: regulation of inflammatory response
Cellular component: extracellular space

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF09294
Domain description: Interferon-alpha/beta receptor, fibronectin type III
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
The deposited structure of PDB entry 4doh contains 2 copies of Pfam domain PF09294 (Interferon-alpha/beta receptor, fibronectin type III) in Interleukin-20 receptor subunit beta. Showing 1 copy in chain B.
The deposited structure of PDB entry 4doh contains 2 copies of Pfam domain PF09294 (Interferon-alpha/beta receptor, fibronectin type III) in Interleukin-20 receptor subunit alpha. Showing 1 copy in chain F [auth E].

PF01108
Domain description: Tissue factor
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
The deposited structure of PDB entry 4doh contains 2 copies of Pfam domain PF01108 (Tissue factor) in Interleukin-20 receptor subunit beta. Showing 1 copy in chain B.
The deposited structure of PDB entry 4doh contains 2 copies of Pfam domain PF01108 (Tissue factor) in Interleukin-20 receptor subunit alpha. Showing 1 copy in chain F [auth E].

PF00726
Domain description: Interleukin 10
Occurring in:
  1. Interleukin-20
The deposited structure of PDB entry 4doh contains 2 copies of Pfam domain PF00726 (Interleukin 10) in Interleukin-20. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
IPR020444
Domain description: Interleukin-24
Occurring in:
  1. Interleukin-20
IPR015373
Domain description: Interferon/interleukin receptor domain
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
IPR020443
Domain description: Interleukin-10/19/20/22/24/26 family
Occurring in:
  1. Interleukin-20
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-20
IPR020423
Domain description: Interleukin-10, conserved site
Occurring in:
  1. Interleukin-20

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Interleukin-20 receptor subunit beta
  2. Interleukin-20 receptor subunit alpha
The deposited structure of PDB entry 4doh contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-20 receptor subunit beta. Showing 2 copies in chain B.
The deposited structure of PDB entry 4doh contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-20 receptor subunit alpha. Showing 2 copies in chain F [auth E].
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-20
The deposited structure of PDB entry 4doh contains 2 copies of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-20. Showing 1 copy in chain A.

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