4doh

X-ray diffraction
2.8Å resolution

IL20/IL201/IL20R2 Ternary Complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-20 Chains: A, C
Molecule details ›
Chains: A, C
Length: 153 amino acids
Theoretical weight: 17.63 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q9NYY1 (Residues: 25-176; Coverage: 100%)
Gene names: IL20, UNQ852/PRO1801, ZCYTO10
Structure domains: Growth Hormone; Chain: A;
Interleukin-20 receptor subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 206 amino acids
Theoretical weight: 23.05 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q6UXL0 (Residues: 30-231; Coverage: 72%)
  • Best match: Q6UXL0-3 (Residues: 1-131)
Gene names: DIRS1, IL20RB, UNQ557/PRO1114
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins
Interleukin-20 receptor subunit alpha Chains: E, R
Molecule details ›
Chains: E, R
Length: 221 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q9UHF4 (Residues: 29-245; Coverage: 41%)
Gene names: IL20RA, UNQ681/PRO1315
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 103.115Å b: 111.764Å c: 136.334Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.278
Expression system: Drosophila