4djh

X-ray diffraction
2.9Å resolution

Structure of the human kappa opioid receptor in complex with JDTic

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Kappa-type opioid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 54.29 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41145 (Residues: 43-261, 263-358; Coverage: 83%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: E, OPRK, OPRK1
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 54.896Å b: 147.297Å c: 205.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.265
Expression system: Spodoptera frugiperda