X-ray diffraction
2.9Å resolution

Crystal structure of domains 1 and 2 of LRP6

Source organism: Homo sapiens
Entry authors: Ceska TA, Doyle C, Slocombe P

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 616 amino acids
Theoretical weight: 69.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: O75581 (Residues: 20-635; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P3121
Unit cell:
a: 109.36Å b: 109.36Å c: 130.88Å
α: 90° β: 90° γ: 120°
R R work R free
0.257 0.257 0.313
Expression system: Cricetulus griseus