4deq

X-ray diffraction
2.65Å resolution

Structure of the Neuropilin-1/VEGF-A complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1; Vascular endothelial growth factor A Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14786 (Residues: 274-429; Coverage: 17%)
  • Canonical: P15692 (Residues: 183-232; Coverage: 24%)
Gene names: NRP, NRP1, VEGF, VEGF165R, VEGFA
Sequence domains: F5/8 type C domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43
Unit cell:
a: 114.978Å b: 114.978Å c: 50.946Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.267
Expression system: Escherichia coli