› 4d86

X-ray diffraction
2Å resolution

Human PARP14 (ARTD8, BAL2) - macro domains 1 and 2 in complex with adenosine-5-diphosphate

Released:
DOI: 10.2210/pdb4d86/pdb
PDB 4d86 coloured by chain and viewed from the front.
PDB 4d86 coloured by chain and viewed from the side.
PDB 4d86 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B
Structure 21 462-75 (2013)
PMID: 23473667

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP14 Chain: A
Molecule details ›
Chain: A
Length: 415 amino acids
Theoretical weight: 44.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N5 (Residues: 784-1196; Coverage: 23%)
Gene names: BAL2, KIAA1268, PARP14
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

1 bound ligand:
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P2221
Unit cell:
a: 46.6Å b: 60.027Å c: 145.072Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.238
Expression system: Escherichia coli

Quick links

Citations

16 review citations

ADP-ribosylation in evasion, promotion and exacerbation of immune responses.
Rosado et al. (2021)
15 more

3 mentions without citation

Research Progress on PARP14 as a Drug Target.
Qin et al. (2019)
2 more