4cyy

X-ray diffraction
2.89Å resolution

The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

Released:
Source organism: Homo sapiens
Primary publication:
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Acta Crystallogr. D Biol. Crystallogr. 70 3320-9 (2014)
PMID: 25478849

Function and Biology Details

Reaction catalysed:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantetheinase Chain: A
Molecule details ›
Chain: A
Length: 506 amino acids
Theoretical weight: 56.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95497 (Residues: 27-513; Coverage: 99%)
Gene name: VNN1
Sequence domains: Carbon-nitrogen hydrolase
Structure domains: Carbon-nitrogen hydrolase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3221
Unit cell:
a: 101.904Å b: 101.904Å c: 133.652Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.219
Expression system: Homo sapiens