› 4csr

X-ray diffraction
1.5Å resolution

High resolution crystal structure of the histone fold dimer (NF-YB)-(NF-YC)

Released:
DOI: 10.2210/pdb4csr/pdb
PDB 4csr coloured by chain and viewed from the front.
PDB 4csr coloured by chain and viewed from the side.
PDB 4csr coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Gnesutta N, Cocolo S, Mantovani R, Bolognesi M, Nardini M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear transcription factor Y subunit beta Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25208 (Residues: 51-143; Coverage: 45%)
Gene names: HAP3, NFYB
Sequence domains: Histone-like transcription factor (CBF/NF-Y) and archaeal histone
Structure domains: Histone, subunit A
Nuclear transcription factor Y subunit gamma Chain: B
Molecule details ›
Chain: B
Length: 94 amino acids
Theoretical weight: 11.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13952 (Residues: 27-120; Coverage: 21%)
Gene name: NFYC
Sequence domains: Core histone H2A/H2B/H3/H4
Structure domains: Histone, subunit A

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 51.67Å b: 60.8Å c: 61.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.145 0.184
Expression system: Escherichia coli

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