X-ray diffraction
2.75Å resolution

Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS

Source organism: Homo sapiens
Entry authors: Mathea S, Elkins JM, Shrestha L, Szklarz M, Tallant C, Newman JA, Cooper CD, Shrestha B, Tumber A, Cocking R, Salah E, von Delft F, Arrowsmith C, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase N2 Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 39.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q16513 (Residues: 646-984; Coverage: 35%)
Gene names: PKN2, PRK2, PRKCL2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 68.639Å b: 68.639Å c: 185.473Å
α: 90° β: 90° γ: 120°
R R work R free
0.213 0.21 0.262
Expression system: Spodoptera frugiperda