› 4cri

X-ray diffraction
2.35Å resolution

Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide

Released:
DOI: 10.2210/pdb4cri/pdb
PDB 4cri coloured by chain and viewed from the front.
PDB 4cri coloured by chain and viewed from the side.
PDB 4cri coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Krojer T, Johansson C, Gileadi C, Fedorov O, Carr S, La Thangue NB, Vollmar M, Crawley L, von Delft F, Bountra C, Arrowsmith CH, Edwards A, Oppermann U

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TP53-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 19.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12888 (Residues: 1459-1634; Coverage: 9%)
Gene name: TP53BP1
Sequence domains: Tumour suppressor p53-binding protein-1 Tudor
Structure domains:
Retinoblastoma-associated protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 17 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06400 (Residues: 802-817; Coverage: 2%)
Gene name: RB1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MLY 2 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6122
Unit cell:
a: 105.789Å b: 105.789Å c: 156.153Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.23
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

Oncogene or Tumor Suppressor: The Coordinative Role of Lysine Methyltransferase SET7/9 in Cancer Development and the Related Mechanisms.
Gu et al. (2022)
9 more

1 mention without citation

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
Carr et al. (2014)