X-ray diffraction
2.35Å resolution

Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide

Source organism: Homo sapiens
Entry authors: Krojer T, Johansson C, Gileadi C, Fedorov O, Carr S, La Thangue NB, Vollmar M, Crawley L, von Delft F, Bountra C, Arrowsmith CH, Edwards A, Oppermann U

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TP53-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 19.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q12888 (Residues: 1459-1634; Coverage: 9%)
Gene name: TP53BP1
Sequence domains: Tumour suppressor p53-binding protein-1 Tudor
Structure domains:
Retinoblastoma-associated protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 17 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P06400 (Residues: 802-817; Coverage: 2%)
Gene name: RB1

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6122
Unit cell:
a: 105.789Å b: 105.789Å c: 156.153Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.194 0.23
Expression systems:
  • Escherichia coli
  • Not provided