X-ray diffraction
2.8Å resolution

Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CCR4-NOT transcription complex subunit 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 535 amino acids
Theoretical weight: 61.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: A5YKK6 (Residues: 1833-2361; Coverage: 22%)
Gene names: AD-005, CDC39, CNOT1, KIAA1007, NOT1
Sequence domains: CCR4-Not complex component, Not1
Nanos homolog 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 17 amino acids
Theoretical weight: 1.9 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q8WY41 (Residues: 40-56; Coverage: 6%)
Gene names: NANOS1, NOS1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 96.53Å b: 167.33Å c: 112.04Å
α: 90° β: 90° γ: 90°
R R work R free
0.223 0.222 0.243
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided