4cof

X-ray diffraction
2.97Å resolution

Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of a human GABAA receptor.
OpenAccess logo Nature (2014)
PMID: 24909990

Function and Biology Details

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Gamma-aminobutyric acid receptor subunit beta-3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 355 amino acids
Theoretical weight: 40.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P28472 (Residues: 26-332, 447-473; Coverage: 75%)
Gene name: GABRB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 174.1Å b: 108.9Å c: 207.44Å
α: 90° β: 107.43° γ: 90°
R-values:
R R work R free
0.206 0.205 0.226
Expression system: Homo sapiens