4cmm

X-ray diffraction
1.92Å resolution

Structure of human CD47 in complex with human Signal Regulatory Protein (SIRP) alpha v1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type substrate 1 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.07 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P78324 (Residues: 31-149; Coverage: 25%)
Gene names: BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, SIRPA
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Leukocyte surface antigen CD47 Chain: B
Molecule details ›
Chain: B
Length: 127 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q08722 (Residues: 19-136; Coverage: 39%)
Gene names: CD47, MER6
Sequence domains: CD47 immunoglobulin-like domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P2
Unit cell:
a: 67.39Å b: 32.47Å c: 69.61Å
α: 90° β: 115.06° γ: 90°
R-values:
R R work R free
0.194 0.193 0.228
Expression system: Cricetulus griseus