› 4cmh

X-ray diffraction
1.53Å resolution

Function and Biology Details

Reactions catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210971 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
  • Best match: P28907-2 (Residues: 45-121)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:
HEAVY CHAIN OF SAR650984-FAB FRAGMENT Chain: B
Molecule details ›
Chain: B
Length: 234 amino acids
Theoretical weight: 25.04 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
LIGHT CHAIN OF SAR650984-FAB FRAGMENT Chain: C
Molecule details ›
Chain: C
Length: 214 amino acids
Theoretical weight: 23.51 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 43.619Å b: 111.492Å c: 147.877Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.208
Expression system: Homo sapiens

Quick links

Citations

97 review citations

Mantle Cell Lymphoma.
Cheah et al. (2016)
96 more

12 mentions without citation

The efficacy of high-flow nasal cannula (HFNC) versus non-invasive ventilation (NIV) in patients at high risk of extubation failure: a systematic review and meta-analysis.
Wang et al. (2023)
11 more