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Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor gamma agonist

X-ray diffraction
1.77Å resolution
PDB entry 4ci5 coloured by chain, front view.
PDB entry 4ci5 coloured by chain, side view.
PDB entry 4ci5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 12766.46 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368
Assembly 2
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: monomeric
Accessible surface area: 12381.63 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153368

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma in PDB entry 4ci5, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 4ci5, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 4ci5, assembly 1, top view.
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