X-ray diffraction
1.3Å resolution

Leishmania major N-myristoyltransferase in complex with a thienopyrimidine inhibitor


Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycylpeptide N-tetradecanoyltransferase Chain: A
Molecule details ›
Chain: A
Length: 411 amino acids
Theoretical weight: 47.51 KDa
Source organism: Leishmania major
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q4Q5S8 (Residues: 11-421; Coverage: 98%)
Gene names: LMJF_32_0080, NMT
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments

Cofactor: Ligand MYA 1 x MYA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 47.813Å b: 90.628Å c: 53.2Å
α: 90° β: 111.91° γ: 90°
R R work R free
0.163 0.162 0.196
Expression system: Escherichia coli BL21(DE3)