PDBe 4cde

X-ray diffraction
2.4Å resolution

Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide

Released:

Function and Biology Details

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Dipeptidyl peptidase 1 exclusion domain chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 25-143; Coverage: 27%)
Gene names: CPPI, CTSC
Sequence domains: Cathepsin C exclusion domain
Structure domains: Cathepsin C, exclusion domain
Dipeptidyl peptidase 1 heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 165 amino acids
Theoretical weight: 18.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 230-394; Coverage: 38%)
Gene names: CPPI, CTSC
Structure domains: Cysteine proteinases
Dipeptidyl peptidase 1 light chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 69 amino acids
Theoretical weight: 7.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 395-463; Coverage: 16%)
Gene names: CPPI, CTSC
Structure domains: Cysteine proteinases. Chain C

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P3121
Unit cell:
a: 84.35Å b: 84.35Å c: 224.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.242
Expression system: Spodoptera frugiperda