4cdd › Citations

Cathepsin C inhibitors: property optimization and identification of a clinical candidate.

Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K
J Med Chem 57 2357-67 (2014)
Related entries: 4cdc, 4cde, 4cdf

Cited: 13 times
EuropePMC logo PMID: 24592859

Abstract

A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.

Articles - 4cdd mentioned but not cited (1)

  1. DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines. Käck H, Doyle K, Hughes SJ, Bodnarchuk MS, Lönn H, Van De Poël A, Palmer N. ACS Med Chem Lett 10 1222-1227 (2019)


Reviews citing this publication (3)

  1. Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Siklos M, BenAissa M, Thatcher GR. Acta Pharm Sin B 5 506-519 (2015)
  2. Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS? Korkmaz B, Lesner A, Marchand-Adam S, Moss C, Jenne DE. J Med Chem 63 13258-13265 (2020)
  3. Dipeptidyl peptidase 1 inhibition as a potential therapeutic approach in neutrophil-mediated inflammatory disease. Chalmers JD, Kettritz R, Korkmaz B. Front Immunol 14 1239151 (2023)

Articles citing this publication (9)

  1. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, Cravatt BF. Cell Chem Biol 24 1388-1400.e7 (2017)
  2. Neutrophil maturation rate determines the effects of dipeptidyl peptidase 1 inhibition on neutrophil serine protease activity. Gardiner P, Wikell C, Clifton S, Shearer J, Benjamin A, Peters SA. Br J Pharmacol 173 2390-2401 (2016)
  3. Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C. Lenartowicz P, Makowski M, Oszywa B, Haremza K, Latajka R, Pawełczak M, Kafarski P. Biochimie 139 46-55 (2017)
  4. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. PLoS One 14 e0226270 (2019)
  5. Focusing on probe-modified peptides: a quick and effective method for target identification. Sun H, Ren Y, Hou W, Li L, Zeng F, Li S, Ma Y, Liu X, Chen S, Zhang Z. Chem Commun (Camb) 52 10225-10228 (2016)
  6. Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors. de Vries LE, Sanchez MI, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, Deu E. FEBS J 286 3998-4023 (2019)
  7. Electrochemical Synthesis of Unnatural Amino Acids via Anodic Decarboxylation of N-Acetylamino Malonic Acid Derivatives. Koleda O, Prane K, Suna E. Org Lett 25 7958-7962 (2023)
  8. Synthesis of 2 C-14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole. Kingston L, Bergare J, Lönn H, Ericsson C, Grönberg G, Chen S, Elmore CS. J Labelled Comp Radiopharm 60 294-301 (2017)
  9. The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors. Allen P, Bragg RA, Caffrey M, Ericsson C, Hickey MJ, Kingston LP, Elmore CS. J Labelled Comp Radiopharm 60 124-129 (2017)


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