› › Function and Biology

60S ribosomal protein L8 histidine hydroxylase (NO66 S373C) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G214C) peptide fragment (complex-3)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 1.14.11.27: [Histone H3]-dimethyl-L-lysine(36) demethylase

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(36) + succinate + formaldehyde + CO(2)
Systematic name:
[Histone H3]-N(6),N(6)-dimethyl-L-lysine(36),2-oxoglutarate:oxygen oxidoreductase
Alternative Name(s):
  • H3-K36-specific demethylase
  • Histone demethylase
  • Histone-lysine (H3-K36) demethylase
  • JHDM1A
  • JmjC domain-containing histone demethylase 1A
  • Protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
  • [Histone-H3]-lysine-36 demethylase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21233
Domain description: Ribosomal oxygenase 1, C-terminal winged helix domain
Occurring in:
  1. Ribosomal oxygenase 1
The deposited structure of PDB entry 4cco contains 2 copies of Pfam domain PF21233 (Ribosomal oxygenase 1, C-terminal winged helix domain) in Ribosomal oxygenase 1. Showing 1 copy in chain B.

PF08007
Domain description: JmjC domain
Occurring in:
  1. Ribosomal oxygenase 1
The deposited structure of PDB entry 4cco contains 2 copies of Pfam domain PF08007 (JmjC domain) in Ribosomal oxygenase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003347
Domain description: JmjC domain
Occurring in:
  1. Ribosomal oxygenase 1
IPR014726
Domain description: Large ribosomal subunit protein uL2, domain 3
Occurring in:
  1. Large ribosomal subunit protein uL2
IPR008991
Domain description: Translation protein SH3-like domain superfamily
Occurring in:
  1. Large ribosomal subunit protein uL2
IPR039994
Domain description: Histone lysine demethylase/ribosomal histidine hydroxylase NO66-like
Occurring in:
  1. Ribosomal oxygenase 1

Structure domains

CATH CATH domains
3.90.930.40
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Outer Surface Protein A; domain 3
Homology: Outer Surface Protein A; domain 3
Occurring in:
  1. Ribosomal oxygenase 1
The deposited structure of PDB entry 4cco contains 2 copies of CATH domain 3.90.930.40 (Outer Surface Protein A; domain 3) in Ribosomal oxygenase 1. Showing 1 copy in chain B.
1.10.10.1500
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: JmjC domain-containing ribosomal oxygenase (ROX), dimer domain
Occurring in:
  1. Ribosomal oxygenase 1
The deposited structure of PDB entry 4cco contains 2 copies of CATH domain 1.10.10.1500 (Arc Repressor Mutant, subunit A) in Ribosomal oxygenase 1. Showing 1 copy in chain B.
2.60.120.650
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Cupin
Occurring in:
  1. Ribosomal oxygenase 1
The deposited structure of PDB entry 4cco contains 2 copies of CATH domain 2.60.120.650 (Jelly Rolls) in Ribosomal oxygenase 1. Showing 1 copy in chain B.

Quick links