› 4c9j

X-ray diffraction
3.4Å resolution

Structure of yeast mitochondrial ADP/ATP carrier isoform 3 inhibited by carboxyatractyloside (P212121 crystal form)

Released:
DOI: 10.2210/pdb4c9j/pdb
PDB entry 4c9j coloured by chain, front view.
PDB entry 4c9j coloured by chain, side view.
PDB entry 4c9j coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism.
Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER
Proc Natl Acad Sci U S A 111 E426-34 (2014)
PMID: 24474793

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148333 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP,ATP carrier protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 35.26 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P18238 (Residues: 3-307; Coverage: 99%)
Gene names: AAC3, YBR0753, YBR085W
Sequence domains: Mitochondrial carrier protein
Structure domains: Mitochondrial carrier domain

Ligands and Environments

2 bound ligands:
Ligand CXT 2 x CXT
Ligand CDL 6 x CDL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 40.286Å b: 104.168Å c: 154.143Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.25 0.297
Expression system: Saccharomyces cerevisiae

Quick links

Citations

31 review citations

Metabolism and function of mitochondrial cardiolipin.
Ren et al. (2014)
30 more

10 mentions without citation

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
9 more