4c6v

X-ray diffraction
2.7Å resolution

Crystal structure of M. tuberculosis KasA in complex with TLM5 (Soak for 5 min)

Released:
Entry authors: Schiebel J, Kapilashrami K, Fekete A, Bommineni GR, Schaefer CM, Mueller MJ, Tonge PJ, Kisker C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1 Chain: A
Molecule details ›
Chain: A
Length: 439 amino acids
Theoretical weight: 45.82 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3121
Unit cell:
a: 77.23Å b: 77.23Å c: 146.851Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.176 0.242
Expression system: Mycolicibacterium smegmatis