4c58

X-ray diffraction
2.16Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-G-associated kinase Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 38.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14976 (Residues: 14-351; Coverage: 26%)
Gene name: GAK
Sequence domains: Protein kinase domain
Structure domains:
nanobody Chain: B
Molecule details ›
Chain: B
Length: 140 amino acids
Theoretical weight: 15.09 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 156.866Å b: 37.43Å c: 76.01Å
α: 90° β: 108.48° γ: 90°
R-values:
R R work R free
0.182 0.179 0.242
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli