PDBe 4c2x

X-ray diffraction
2.33Å resolution

Human N-myristoyltransferase isoform 2 (NMT2)

Released:

Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 410 amino acids
Theoretical weight: 47.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60551 (Residues: 112-498; Coverage: 78%)
Gene name: NMT2
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand NHW 1 x NHW
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 49.7Å b: 72.32Å c: 114.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.218 0.288
Expression system: Escherichia coli BL21(DE3)