4c0o

X-ray diffraction
2.56Å resolution

Transportin 3 in complex with phosphorylated ASF/SF2

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 923 amino acids
Theoretical weight: 104.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: Q9Y5L0 (Residues: 1-923)
Gene names: IPO12, TNPO3
Serine/arginine-rich splicing factor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 125 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: Q07955 (Residues: 106-230)
Gene names: ASF, OK/SW-cl.3, SF2, SF2P33, SFRS1, SRSF1

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P1
Unit cell:
a: 80.552Å b: 91.062Å c: 98.122Å
α: 106.98° β: 100.3° γ: 102.18°
R-values:
R R work R free
0.224 0.221 0.269
Expression system: Escherichia coli BL21(DE3)