4c02

X-ray diffraction
2.17Å resolution

Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activin receptor type-1 Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 37.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04771 (Residues: 172-499; Coverage: 67%)
Gene names: ACVR1, ACVRLK2
Sequence domains:
Structure domains:
Peptidyl-prolyl cis-trans isomerase FKBP1B Chain: B
Molecule details ›
Chain: B
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P4132
Unit cell:
a: 182.33Å b: 182.33Å c: 182.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.198
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli BL21(DE3)