4bzo

X-ray diffraction
2.1Å resolution

Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 2-313; Coverage: 100%)
Gene name: PIM1
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P65
Unit cell:
a: 97.932Å b: 97.932Å c: 81.431Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.216
Expression system: Escherichia coli