4bz5

X-ray diffraction
1.78Å resolution

Crystal structure of Schistosoma mansoni HDAC8

Released:
Source organism: Schistosoma mansoni
Entry authors: Marek M, Romier C

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hist_deacetyl domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 446 amino acids
Theoretical weight: 50.44 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5H660 (Residues: 1-440; Coverage: 100%)
Gene name: HDAC8
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 70.649Å b: 70.734Å c: 98.295Å
α: 75.9° β: 78.32° γ: 85.59°
R-values:
R R work R free
0.156 0.154 0.188
Expression system: Escherichia coli BL21(DE3)