Structure analysis

Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state

X-ray diffraction
2.74Å resolution
Source organism: Homo sapiens
Assembly composition:
Non-polymer only dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: Non-polymer only dimer
Accessible surface area: 38300 Å2
Buried surface area: 4900 Å2
Dissociation area: 1,900 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -42 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: Non-polymer only dimer
Accessible surface area: 38700 Å2
Buried surface area: 4700 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 14 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -33 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, C
Length: 725 amino acids
Theoretical weight: 83.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00159 (Residues: 36-760; Coverage: 68%)
Gene name: MYO1C
Pfam:
InterPro:

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Chains: B, D
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Pfam: EF-hand domain pair
InterPro:

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