› 4byf

X-ray diffraction
2.74Å resolution

Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state

Released:
DOI: 10.2210/pdb4byf/pdb
PDB 4byf coloured by chain and viewed from the front.
PDB 4byf coloured by chain and viewed from the side.
PDB 4byf coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca(2+)-Regulation and 14-3-3 Binding.
Stefan Münnich MH, Manstein DJ
J. Mol. Biol. (2014)
PMID: 24636949

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-Ic Chains: A, C
Molecule details ›
Chains: A, C
Length: 725 amino acids
Theoretical weight: 83.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00159 (Residues: 36-760; Coverage: 68%)
Gene name: MYO1C
Sequence domains:
Calmodulin-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:
Ligand MG 3 x MG
Ligand AOV 2 x AOV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 59.58Å b: 158.45Å c: 114.34Å
α: 90° β: 91.56° γ: 90°
R-values:
R R work R free
0.183 0.183 0.237
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis.
Villalobo et al. (2020)
6 more

7 mentions without citation

Kinetic Adaptations of Myosins for Their Diverse Cellular Functions.
Heissler et al. (2016)
6 more