EC 2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme
Reaction catalysed:
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
Alternative Name(s):
- E2-230K
- E3-independent ubiquitin-conjugating enzyme E2
- UBE2O
EC 2.3.2.23: E2 ubiquitin-conjugating enzyme
Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
- UBC
- Ubiquitin-carrier-protein E2
- Ubiquitin-conjugating enzyme E2
GO terms
Biochemical function:
Biological process:
- positive regulation of protein targeting to mitochondrion
- protein K6-linked ubiquitination
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein autoubiquitination
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein modification process
- negative regulation of BMP signaling pathway
- protein ubiquitination
- DNA damage response
- apoptotic process
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- DNA repair
- protein polyubiquitination
- negative regulation of transcription by RNA polymerase II
- protein autophosphorylation
- phosphorylation
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotationsStructure domains
CATH domains
3.10.20.90
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
3.10.110.10
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin Conjugating Enzyme
Homology:
Ubiquitin Conjugating Enzyme
Occurring in:
1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
