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SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD

X-ray diffraction
1.9Å resolution
PDB entry 4buz coloured by chain, front view.
PDB entry 4buz coloured by chain, side view.
PDB entry 4buz coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NAD-dependent protein deacetylase and Cellular tumor antigen p53
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Multimeric state: hetero dimer
Accessible surface area: 11032.59 Å2
Buried surface area: 3578.33 Å2
Dissociation area: 1,190.76 Å2
Dissociation energy (ΔGdiss): 17.32 kcal/mol
Dissociation entropy (TΔSdiss): 8.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138128

Macromolecules

NAD-dependent protein deacetylase
Chain: A
Length: 246 amino acids
Theoretical weight: 27.57 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WYW0 (Residues: 1-246; Coverage: 100%)
Gene names: TM_0490, cobB, sir2
Pfam: Sir2 family
InterPro:
CATH:
NAD-dependent protein deacetylase in PDB entry 4buz, assembly 1, front view.
NAD-dependent protein deacetylase in PDB entry 4buz, assembly 1, side view.
NAD-dependent protein deacetylase in PDB entry 4buz, assembly 1, top view.
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Cellular tumor antigen p53
Chain: P
Length: 8 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 379-386; Coverage: 2%)
Gene names: P53, TP53
Cellular tumor antigen p53 in PDB entry 4buz, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 4buz, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 4buz, assembly 1, top view.
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