› 4bum

X-ray diffraction
2.8Å resolution

Crystal structure of the Voltage Dependant Anion Channel 2 from zebrafish.

Released:
DOI: 10.2210/pdb4bum/pdb
PDB entry 4bum coloured by chain, front view.
PDB entry 4bum coloured by chain, side view.
PDB entry 4bum coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.
Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J
J Biol Chem 289 12566-77 (2014)
PMID: 24627492

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent anion-selective channel protein 2 Chain: X
Molecule details ›
Chain: X
Length: 289 amino acids
Theoretical weight: 31.15 KDa
Source organism: Danio rerio
Expression system: Escherichia coli M15
UniProt:
  • Canonical: Q8AWD0 (Residues: 1-283; Coverage: 100%)
Gene names: vdac2, wu:fa01a08, wu:fa98a10, wu:fb50g11, zgc:55795, zgc:77621
Sequence domains: Eukaryotic porin
Structure domains: Porin

Ligands and Environments

1 bound ligand:
Ligand LDA 1 x LDA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3221
Unit cell:
a: 72.47Å b: 72.47Å c: 177.95Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.246 0.282
Expression system: Escherichia coli M15

Quick links

Citations

24 review citations

ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect.
Maldonado et al. (2014)
23 more

19 mentions without citation

VDAC2-specific cellular functions and the underlying structure.
Naghdi et al. (2016)
18 more