4bqv

X-ray diffraction
1.7Å resolution

MOUSE CATHEPSIN S WITH COVALENT LIGAND

Released:
Source organism: Mus musculus
Entry authors: Banner DW, Benz J, Gsell B, Stihle M, Ruf A, Haap W

Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin S Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 225 amino acids
Theoretical weight: 24.66 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O70370 (Residues: 116-340; Coverage: 70%)
Gene names: Cats, Ctss
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 63.884Å b: 66.984Å c: 103.33Å
α: 90.04° β: 96.68° γ: 89.9°
R-values:
R R work R free
0.204 0.202 0.24
Expression system: Escherichia coli