Structure analysis

Crystal structure of the RGMB-NEO1 complex form 3

X-ray diffraction
2.8Å resolution
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 18000 Å2
Buried surface area: 4800 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 5 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -20 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 213 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P97798 (Residues: 883-1083; Coverage: 14%)
Gene names: Neo1, Ngn
Pfam: Fibronectin type III domain
InterPro:
CATH: Immunoglobulins

Search similar proteins

Chain: B
Length: 122 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 50-168; Coverage: 30%)
Gene name: RGMB
InterPro:

Search similar proteins

Chain: C
Length: 251 amino acids
Theoretical weight: 27.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 169-410; Coverage: 62%)
Gene name: RGMB
Pfam: Repulsive guidance molecule (RGM) C-terminus
InterPro:
CATH: Mog1/PsbP, alpha/beta/alpha sandwich

Search similar proteins