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Crystal structure of the RGMB-NEO1 complex form 3

X-ray diffraction
2.8Å resolution
PDB 4bq8 coloured by chain and viewed from the front.
PDB 4bq8 coloured by chain and viewed from the side.
PDB 4bq8 coloured by chain and viewed from the top.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18000 Å2
Buried surface area: 4800 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 5 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -20 kcal/mol
Symmetry number: 1

Macromolecules

Neogenin
Chain: A
Length: 213 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P97798 (Residues: 883-1083; Coverage: 14%)
Gene names: Neo1, Ngn
Pfam: Fibronectin type III domain
InterPro:
CATH: Immunoglobulins
PDB 4bq8 contains 1 copy of Neogenin in assembly 1. This protein is highlighted and viewed from the front.
PDB 4bq8 contains 1 copy of Neogenin in assembly 1. This protein is highlighted and viewed from the side.
PDB 4bq8 contains 1 copy of Neogenin in assembly 1. This protein is highlighted and viewed from the top.
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RGM domain family member B
Chain: B
Length: 122 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 50-168; Coverage: 30%)
Gene name: RGMB
InterPro:
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the front.
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the side.
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the top.
Molecule details ›

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RGM domain family member B
Chain: C
Length: 251 amino acids
Theoretical weight: 27.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 169-410; Coverage: 62%)
Gene name: RGMB
Pfam: Repulsive guidance molecule (RGM) C-terminus
InterPro:
CATH: Mog1/PsbP, alpha/beta/alpha sandwich
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the front.
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the side.
PDB 4bq8 contains 1 copy of RGM domain family member B in assembly 1. This protein is highlighted and viewed from the top.
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