Function and Biology

Enoyl-ACP reductase from Yersinia pestis (wildtype)with cofactor NADH

Source organism: Yersinia pestis A1122
Biochemical function: NAD binding
Biological process: fatty acid biosynthetic process
Cellular component: not assigned

EC 1.3.1.9: Enoyl-[acyl-carrier-protein] reductase (NADH)

Reaction catalysed:
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Systematic name:
Acyl-[acyl-carrier protein]:NAD(+) oxidoreductase
Alternative Name(s):
  • Acyl-[acyl-carrier-protein]:NAD(+) oxidoreductase
  • Enoyl-ACP reductase
  • Enoyl-[acyl carrier protein] reductase
  • FabI (gene name)
  • InhA (gene name)
  • NADH-enoyl acyl carrier protein reductase
  • NADH-specific enoyl-ACP reductase

Sequence families

Pfam Protein families (Pfam)
PF07055
Domain description: Enoyl reductase FAD binding domain
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 4bkq contains 1 copy of Pfam domain PF07055 (Enoyl reductase FAD binding domain) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain A.

PF12241
Domain description: Trans-2-enoyl-CoA reductase catalytic region
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 4bkq contains 1 copy of Pfam domain PF12241 (Trans-2-enoyl-CoA reductase catalytic region) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain A.

PF12242
Domain description: NAD(P)H binding domain of trans-2-enoyl-CoA reductase
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 4bkq contains 1 copy of Pfam domain PF12242 (NAD(P)H binding domain of trans-2-enoyl-CoA reductase) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010758
Domain description: Trans-2-enoyl-CoA reductase
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
IPR024906
Domain description: Enoyl reductase FAD binding domain
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
IPR024910
Domain description: Trans-2-enoyl-CoA reductase catalytic domain, putative
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Enoyl-[acyl-carrier-protein] reductase [NADH]
The deposited structure of PDB entry 4bkq contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in Enoyl-[acyl-carrier-protein] reductase [NADH]. Showing 1 copy in chain A.